Non disponible en dehors du Royaume-Uni et de l'Irlande
Biochem/physiol Actions
Kd = 15 nM for actin binding
Cell permeable: no
Reversible: no
Product does not compete with ATP.
Primary TargetF-actin
General description
A cell-permeable F-actin probe. This macrocyclic cyclodepsipeptide, isolated from the marine sponge Jaspis johnstoni, is a potent inducer of actin polymerization and stabilization in vitro. It competes with Phalloidin (Cat. No. 516640) for actin binding (Kd = 15 nM) and enhances apoptosis induced by interleukin 2 (IL-2) deprivation. Also displays fungicidal, insecticidal, and anticancer properties.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Other Notes
Rosado, J.A., et al. 2000. J. Biol. Chem.275, 7527.Posey, S.C., and Bierer, B.E. 1999. J. Biol. Chem.274, 4259.Senderowicz, A.M., et al. 1995. J. Natl. Cancer Inst.87, 46.Bubb, M.R., et al. 1994. J. Biol. Chem.269, 14869.Scott, V.R., et al. 1988. Antimicrob. Agents Chemother.32, 1154.
Packaging
Packaged under inert gas
50 µg in Plastic ampoule
Physical form
A 1 mM (50 µg/71 µl) solution of Jasplakinolide, Jaspis johnstoni (Cat. No. 420107) in DMSO.
Reconstitution
Following initial thaw, aliquot and freeze (-20°C).
Warning
Toxicity: Harmful (C)
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