Non disponible en dehors du Royaume-Uni et de l'Irlande
General description
A cell-permeable tetrahydroisoquinolinylidene compound that modulates Wnt/β-catenin signaling by targeting the PR72/130 subunit of PP2A and thereby blocking PP2A/Nkd complex formation, resulting in diminished β-catenin/p300 interaction and a concomitant increase in β-catenin/CBP usage. Co-adminitration of IQ-1 (4 µg/ml) and Wnt3a (100 ng/ml), but neither reagent alone, has been shown to be sufficient in maintaining long-term (>48 days) murine ESCs (Embryonic Stem Cells) pluripotency in the absence of serum.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Other Notes
Miyabayashi, T., et al. 2007. Proc. Natl. Acad. Sci. USA104, 5668.
Packaging
Packaged under inert gas
10 mg in Plastic ampoule
Warning
Toxicity: Standard Handling (A)
Ce produit répond aux critères suivants pour être admissible aux récompenses suivantes :