10:0 PA

Non disponible en dehors du Royaume-Uni et de l'Irlande

Application

10:0 PA may be used:as a component in the lipid bilayer to study how lipid geometry acts in coat protein I (COPI) vesicle fission to study its effects on intracellular Ca²⁺concentration ([Ca²⁺]i) in C6 rat glioma and L2071 mouse fibroblast cellsto activate protein kinase C (PKC)as a cell-free activator in membrane and cytosolic fractions for nicotinamide adenine dinucleotide phosphate (NADPH) oxidase assay

Biochem/physiol Actions

Phosphatidic acid (PA) serves as a lipid second messenger. It can control membrane shape. It is known to participate in cell proliferation, vesicular trafficking, cytoskeletal organization and signal transduction. PA can stimulate negative curvature in lamellar lipid structures. It can block the enzymatic activity of protein phosphatase 1 (PP1).

General description

Phosphatidic acid (PA), a minor constituent of biological membranes is a simplest glycerophospholipid. It has glycerol backbone with phosphate present at C-3 position. The C-1 and C-2 positions are esterified with fatty acids.

Packaging

5 mL Clear Glass Sealed Ampule (830843P-25mg)

30 mL Amber Wide Mouth Bottle with Screw Cap (830843P-500mg)