Non disponible en dehors du Royaume-Uni et de l'Irlande
Application
For research use only. Not for use in diagnostic procedures.Mouse Shh-N ELISA Kit has been used to measure serum sonic hedgehog (Shh) level.
Biochem/physiol Actions
Sonic hedgehog (Shh) is a secreted glycoprotein involved in embryonic morphogenic development of several tissues. It has a role in fracture healing and regeneration. In the canonical pathway, the protein associates with its receptor Patched (Ptc-1), de-represses Smoothened (Smo) and activates the Gli family of transcription factors. Mutations in the Shh pathway have been linked to developmental diseases and cancer. Shh plays a vital role in axon growth and guidance throughout the brain development. Shh stimulates neurite outgrowth by overcoming neurite growth inhibitory environment associated with glial scar.
General description
The Mouse Shh-N (Sonic Hedgehog N Terminus) ELISA (Enzyme-Linked Immunosorbent Assay) kit is an in vitro enzyme-linked immunosorbent assay for the quantitative measurement of mouse Shh-N in serum, plasma, cell culture supernatants and urine.
Immunogen
Recombinant Mouse Sonic Hedgehog (N-terminus)
Other Notes
A sample Certificate of Analysis is available for this product.Please type the word sample in the text box provided for lot number.
Ce produit répond aux critères suivants pour être admissible aux récompenses suivantes :