Facteur de complément H à partir du plasma humain, 1 mg/mL en polyméthylpentène, pH 7,2, > = 90% (SDS- PAGE)

Non disponible en dehors du Royaume-Uni et de l'Irlande

Application

Complement factor H (CFH) is a plasma regulator of the complement protein C3b in the alternative pathway of the complement system. Research has shown that binding of CFH is important for pathogenesis of group A streptococcus (GAS), and inhibition of this binding may be an effective management of GAS infections.

Biochem/physiol Actions

C3b-binding protein which regulates the formation and function of complement C3 and C5 convertases.

Complement factor H plays an essential role in the homeostasis of the complement system and in preventing collateral damage to bystander cells and tissues by complement activation.

Other Notes

View more information on the complement pathway at www.sigma-aldrich.com/enzymeexplorer