Disialoganglioside - GD2 du cerveau bovin, environ 0,95%, poudre lyophile, semisynthétique

Non disponible en dehors du Royaume-Uni et de l'Irlande

Amino Acid Sequence

Cer-Glc-Gal(NeuAc-NeuAc)-GalNAc

Application

Disialoganglioside-GD2 from bovine brain has been used: in the ganglioside- enzyme-linked immunosorbent assay (ELISA)in capture ELISA with anti-GD2 antibody (ch14.18)as a control to test its effect on reactivating autophagy in primary fibroblasts

Biochem/physiol Actions

Disialoganglioside GD2 is expressed in neuroblastoma, melanoma and small cell lung cancer. It is an immunotherapeutic target and is also regarded as a tumor-associated antigen. GD2 may favor cell migrationin tumors by promoting cell growth, as well as extracellular matrix component attachment.

General description

Disialoganglioside GD2 is a cell surface-associated glycosphingolipid, which comprises sialic acid moiety and is regarded as a carbohydrate antigen.. It is expressed in the skin melanocytes, central and peripheral nervous system.

Gangliosides are major constituents of neuronal cell membranes and endoplasmic reticulum; contain a sialated polysaccharide chain linked to ceramide through a β-glycosidic linkage; for classification of gangliosides see Svennerholm, L., et al. (eds.), Structure and Function of Gangliosides, New York, Plenum, 1980.

Packaging

0.1 mg in glass bottle