Anti-PPP1CC antibody produced in chicken, affinity isolated antibody, buffered aqueous solution

Non disponible en dehors du Royaume-Uni et de l'Irlande

Application

Anti-PPP1CC antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.

Biochem/physiol Actions

Serine/threonine-protein phosphatase PP1-γ catalytic subunit is an enzyme encoded by the PPP1CC gene in humans. A novel phosphatidic acid (PA) binding region on PP1c-γ is identified that contains a unique loop-strand structural fold responsible for the interaction with PA. PP1c γ may function as a mediator of PA action in cells. There may be an existence of a specific high affinity PA-binding domain on the enzyme. Its overexpression promotes vascular smooth muscle cell survival by interfering with JNK1 and p⁵³ phosphorylation cascades involved in apoptosis.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Immunogen

Immunogen Sequence: GI # 4506007, sequence 1-323

Recombinant protein phosphatase 1, catalytic subunit, gamma isoform

Physical form

Solution in phosphate buffered saline containing 0.02% sodium azide.