Anti-ewsr1

Non disponible en dehors du Royaume-Uni et de l'Irlande

Application

Anti-EWSR1 antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.

Biochem/physiol Actions

RNA-binding protein EWS is a protein encoded by the EWSR1 gene in humans and is located on human chromosome 22. It is involved in a wide variety of sarcomas as well as some non-mesenchymal tumours. EWSR1 is a ′promiscuous′ gene that can fuse with many different partner genes, resulting in identical tumours. It can partner with the same genes in morphologically and behaviourally different neoplasms. EWSR1 rearrangement is also associated with a variety of salivary gland lesions including classic myoepitheliomas and hyalinizing clear cell carcinomas (HCCCs). It also acts as a novel modulator of cis-acting replication element (CRE) function in hepatitis C virus (HCV) replication.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Immunogen

Immunogen Sequence: GI # 4885225, sequence 380-448

Recombinant ewing sarcoma breakpoint region 1 isoform EWS

Physical form

Solution in phosphate buffered saline containing 0.02% sodium azide.