Anticorps de domaine ANTI - Puma BH3

Non disponible en dehors du Royaume-Uni et de l'Irlande

Analysis Note

ControlWestern Blot : Mouse brain lysate

Application

Anti-Puma BH3 domain Antibody is an antibody against Puma BH3 domain for use in WB.

General description

PUMA is one of the pro-apoptotic Bcl-2 family members including Bax and Noxa, which are also transcriptional targets of p53. The PUMA gene encodes two BH3 domain-containing proteins termed PUMA-a and PUMA-b. PUMA proteins bind Bcl-2, localize to the mitochondria, and induce cytochrome c release and apoptosis in response to p53. PUMA may be a direct mediator of p53-induced apoptosis

Immunogen

This antibody was developed against a synthetic peptide selected from the C-terminal region of human Puma.

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Physical form

Format: Purified

Quality

Western Blot Analysis: 1:250 dilution of this antibody detected Puma BH3 domain on mouse brain lysate.

Specificity

Other species have not been tested.

The antibody reacts with the 21 kDa Puma BH3 domain protein.

Target description

21 kDa