NINTEDANIB

Code: SML2848-5MG D2-231

Non disponible en dehors du Royaume-Uni et de l'Irlande

Biochem/physiol Actions

Nintedanib (BIBF1120) is an orally active, potent ATP-competitive inhibitor against angiokinases VEGFR-1/2/3 (IC50 = 34/21/13 nM), FGFR-1/2...


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Non disponible en dehors du Royaume-Uni et de l'Irlande

Biochem/physiol Actions

Nintedanib (BIBF1120) is an orally active, potent ATP-competitive inhibitor against angiokinases VEGFR-1/2/3 (IC50 = 34/21/13 nM), FGFR-1/2/3/4 (IC50 = 69/37/108/610 nM), PDGFRα/β (IC50 = 59/65 nM), as well as Flt-3, Lck, Lyn, and Src (IC50 = 26, 16, 195, 156 nM, repectively), but not 33 other kinases. Nintedanib exhibits antiangiogenic and antifibrotic efficacy in cultures and in animal models of cancers and pulmonary fibrosis in vivo.

assay≥98% (HPLC)
colorwhite to beige
formpowder
Quality Level100
SMILES stringO=C(NC1=C2)/C(C1=CC=C2C(OC)=O)=C(C3=CC=CC=C3)NC4=CC=C(C=C4)N(C(CN5CCN(CC5)C)=O)C
solubilityDMSO: 2 mg/mL, clear
storage temp.2-8°C
Ce produit répond aux critères suivants pour être admissible aux récompenses suivantes :



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