Non disponible en dehors du Royaume-Uni et de l'Irlande
Application
CL075 has been used to activate the monocyte-derived dendritic cells (DCs) to demonstrate the ability of DCs to induce cell death.
Biochem/physiol Actions
CL075 is a thiazoloquinolone derivative. It might influence tumor development.
CL075 is a selective agonist of Toll-like receptor-8 (TLR-8) with immunostimulant activity. It showed an EC50 value of 400nM for IRF-NFκB stimulation in TLR8 compared to 4 µM for TLR7.
Ce produit répond aux critères suivants pour être admissible aux récompenses suivantes :