AMBRISENTAN

Code: SML2104-10MG D2-231

Non disponible en dehors du Royaume-Uni et de l'Irlande

Biochem/physiol Actions

Ambrisentan is an endothelin receptor antagonist used in the treatment of pulmonary arterial hypertension (PAH). It is 200-fold selective for the the ...


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$180.39 10MG
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Non disponible en dehors du Royaume-Uni et de l'Irlande

Biochem/physiol Actions

Ambrisentan is an endothelin receptor antagonist used in the treatment of pulmonary arterial hypertension (PAH). It is 200-fold selective for the the ETA receptor subtype with a Ki of 1 nM for ETA and a Ki of 195 nM for ETB.

assay≥98% (HPLC)
colorwhite to beige
formpowder
InChI keyOUJTZYPIHDYQMC-UHFFFAOYSA-N
InChI1S/C22H22N2O4/c1-15-14-16(2)24-21(23-15)28-19(20(25)26)22(27-3,17-10-6-4-7-11-17)18-12-8-5-9-13-18/h4-14,19H,1-3H3,(H,25,26)
optical activity[α]/D +160 to +190°, c = 0.5 in methanol
SMILES stringCC1=CC(C)=NC(O[C@@H](C(C2=CC=CC=C2)(OC)C3=CC=CC=C3)C(O)=O)=N1
solubilityDMSO: 2 mg/mL, clear
storage temp.2-8°C
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