LBQ657

Code: SML2064-25MG D2-231

Non disponible en dehors du Royaume-Uni et de l'Irlande

Biochem/physiol Actions

LBQ657 is the active metabolite of sacubitril. It is an inhibitor of the enkephalinase neprilysin (neutral endopeptidase, NEP) formed by the action of...


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$615.21 25MG
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Non disponible en dehors du Royaume-Uni et de l'Irlande

Biochem/physiol Actions

LBQ657 is the active metabolite of sacubitril. It is an inhibitor of the enkephalinase neprilysin (neutral endopeptidase, NEP) formed by the action of esterases on its prodrug sacubitril (AHU377), which is half of the heart failure combination drug Entresto, along with the angiotensin-receptor blocker Valsartan. LBQ657 prevents neprilysin′s degradation of atrial and brain natriuretic peptide, two blood pressure lowering peptides.

assay≥97% (HPLC)
colorwhite to beige
formpowder
optical activity[α]/D -35 to -27°, c = 1 in methanol
shipped inwet ice
SMILES stringOC(CCC(N[C@H](CC1=CC=C(C2=CC=CC=C2)C=C1)C[C@H](C(O)=O)C)=O)=O
solubilityDMSO: 2 mg/mL, clear
storage temp.−20°C
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