SYROSINGOPINE

Code: SML1908-5MG D2-231

Non disponible en dehors du Royaume-Uni et de l'Irlande

Application

Syrosingopine has been used as a monocarboxylate transporter (MCT) inhibitorto study its effects on anti-CD147-induced metabolon disruption in human breast cancer...


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Votre prix
$150.77 5MG
DEMANDER

Non disponible en dehors du Royaume-Uni et de l'Irlande

Application

Syrosingopine has been used as a monocarboxylate transporter (MCT) inhibitorto study its effects on anti-CD147-induced metabolon disruption in human breast cancer cellsto study its effects on Cryptosporidium parvum-infected HCT-8 cellsin orthogonal linear separation analysis (OLSA)-derived decomposed analysis

Biochem/physiol Actions

Syrosingopine is an antihypertensive agent related to reserpine that was found to potentiate the anticancer effects of the antidiabetic agent metformin and phenformin without harmful effects on normal cells. Syrosingopine was also found to potentiate the anticancer activity of mitochondrial electron transport chain (ETC) inhibitors. Its mechanism of action is currently unknown but may involve inhibition of glycolytic enzyme α-enolase rather than its known activity as an inhibitor of vesicular monoamine transporters VMAT1 and VMAT2.

Syrosingopine is a derivative of reserpine and inhibits monocarboxylate lactate transporters 1 and 4 (MCT1/4).

colorwhite to light brown
formpowder
InChI keyZCDNRPPFBQDQHR-SSYATKPKSA-N
InChI1S/C35H42N2O11/c1-7-46-35(40)48-31-26(42-3)12-18(13-27(31)43-4)33(38)47-28-14-19-17-37-11-10-22-21-9-8-20(41-2)15-24(21)36-30(22)25(37)16-23(19)29(32(28)44-5)34(39)45-6/h8-9,12-13,15,19,23,25,28-29,32,36H,7,10-11,14,16-17H2,1-6H3/t19-,23+,25-,28-,29+,32+/m1/s1
Quality Level100
SMILES stringO=C(OC)[C@@H]1[C@]2([H])C[C@@]3([H])C4=C(C5=CC=C(OC)C=C5N4)CCN3C[C@]2([H])C[C@H](OC(C6=CC(OC)=C(OC(OCC)=O)C(OC)=C6)=O)[C@H]1OC
solubilityDMSO: 10 mg/mL, clear
Cas Number84-36-6
Ce produit répond aux critères suivants pour être admissible aux récompenses suivantes :



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