Non disponible en dehors du Royaume-Uni et de l'Irlande

Biochem/physiol Actions

RI(dl)-2 is a cell-permeable pyrroloquinoxaline derivative that selectively inhibits Rad51-mediated D-loop formation (IC₅₀ = 11.1 µM) without affecting its ssDNA-binding activity (IC₅₀ >100 µM). RI(dl)-2 is shown to inhibit DSBs-induced cellular homologous recombination (HR) activity (IC₅₀ = 3.0 µM by HEK293-based DR-GFP reporter assay) by stabilizing nucleoprotein filaments in a nonfunctional state without affecting DNA damage-induced RAD51 nuclear loci formation or stimulating single-strand annealing (SSA) activity.

Packaging

5, 25 mg in glass bottle