OTX015

Code: sml1605-5mg D2-231

Not available outside of the UK & Ireland.

Biochem/physiol Actions

OTX015 is a potent inhibitor of the BET bromodomain proteins 2, 3, and 4 (BRD2/3/4).

It binds to bromodomain and extra-terminal domain (BET) pro...


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$356.74 5MG
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Not available outside of the UK & Ireland.

Biochem/physiol Actions

OTX015 is a potent inhibitor of the BET bromodomain proteins 2, 3, and 4 (BRD2/3/4).

It binds to bromodomain and extra-terminal domain (BET) proteins and inhibits their binding to the chromatin. This in turn prevents gene transcription. OTX015 has been shown to inhibit proliferation of cells in haematological malignancies.

Packaging

5, 25 mg in glass bottle

assay≥98% (HPLC)
colorwhite to light brown
formpowder
Gene Informationhuman ... BRD2(6046), BRD3(8019), BRD4(23476), BRDT(676)
InChI keyGNMUEVRJHCWKTO-FQEVSTJZSA-N
InChI1S/C25H22ClN5O2S/c1-13-14(2)34-25-22(13)23(16-4-6-17(26)7-5-16)28-20(24-30-29-15(3)31(24)25)12-21(33)27-18-8-10-19(32)11-9-18/h4-11,20,32H,12H2,1-3H3,(H,27,33)/t20-/m0/s1
Quality Level100
SMILES stringO=C(NC(C=C1)=CC=C1O)C[C@H]2C3=NN=C(C)N3C(SC(C)=C4C)=C4C(C5=CC=C(Cl)C=C5)=N2
solubilityDMSO: 20 mg/mL, clear
storage temp.2-8°C
Cas Number202590-98-5
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