Non disponible en dehors du Royaume-Uni et de l'Irlande
Biochem/physiol Actions
NSC130813 blocks protein-protein interactions between XPF and ERCC1, two proteins involved in nucleotide excision repair (NER). The compound, NSC130813, blocks repair of DNA damage induced by platinum-based ctyotoxic drugs and DNA alkylating agents. NSC130813 synergistically potentiates cell death in cancer cell lines treated with cisplatin or mitomycin C.
Other Notes
air sensitive
Packaging
5, 25 mg in glass bottle
Ce produit répond aux critères suivants pour être admissible aux récompenses suivantes :