Rp - 8 - Bromo - beta-phenyl-1, N2 - ethenoguanosine 3,5 - sel de sodium monophosphorothioate cyclique, >=98%(HPLC), poudre

Code: B6684-1MG D2-231

Non disponible en dehors du Royaume-Uni et de l'Irlande

Biochem/physiol Actions

Rp-8-Br-PET-cGMPS is metabolically stable, competitive inhibitor of cGMP-dependent protein kinase G. Inhibits both PKG I (Ki = 30 nM) and P...


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Votre prix
$387.71 1MG
DEMANDER

Non disponible en dehors du Royaume-Uni et de l'Irlande

Biochem/physiol Actions

Rp-8-Br-PET-cGMPS is metabolically stable, competitive inhibitor of cGMP-dependent protein kinase G. Inhibits both PKG I (Ki = 30 nM) and PKG II and blocks cGMP-gated retinal type ion channels (IC50 = 25 micromoles).

Features and Benefits

This compound is featured on the PKA & PKG page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Legal Information

U.S. Patent 5,625,056, DE Patent 4,217,679.

Packaging

1, 5 mg in glass bottle

assay≥98% (HPLC)
colorwhite to beige
formpowder
InChI keySVMPQLHYWRTQCX-DBHVCDLJSA-M
InChI1S/C18H15BrN5O6PS.Na/c19-17-21-11-14(24(17)16-12(25)13-10(29-16)7-28-31(27,32)30-13)22-18-20-9(6-23(18)15(11)26)8-4-2-1-3-5-8;/h1-6,10,12-13,16,25H,7H2,(H,20,22)(H,27,32);/q;+1/p-1/t10-,12-,13-,16-,31-;/m1./s1
mp240-300 °C (lit.)
potency30 nM Ki
Quality Level100
SMILES stringO.[Na+].O[C@@H]1[C@@H]2O[P@]([O-])(=S)OC[C@H]2O[C@H]1n3c(Br)nc4C(=O)n5cc(nc5Nc34)-c6ccccc6
solubilityH2O: 15 mg/mL at ≤60 °C
storage temp.−20°C
Cas Number185246-32-6
Ce produit répond aux critères suivants pour être admissible aux récompenses suivantes :



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