GRIA2 (EP387) 0.1 ML

Non disponible en dehors du Royaume-Uni et de l'Irlande

General description

Glutamate receptor 2 (GRIA2) is a ligand-gated ion channel that uses L-glutamate for excitatory synaptic transmission expressed in the central nervous system. A recent gene expression profiling study reported >100 fold GRIA2 induction in solitary fibrous tumors compared with control tissues. Immunohistochemistry studies demonstrated GRIA2 positivity in the majority of solitary fibrous tumors (64-86%). Its diagnostic performance yields 64% sensitivity, 92% specificity, with 41% and 97% positive and negative predictive value, respectively for the differential diagnosis of solitary fibrous tumors versus other mesenchymal soft tissue tumors. GRIA2 may be a useful marker to identify STAT6-negative solitary fibrous tumors.

Other Notes

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Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and &﹤ 0.1% Sodium Azide

Quality