Non disponible en dehors du Royaume-Uni et de l'Irlande
Application
2-Chloro-1-(6-methoxy-1,2,3,4-tetrahydroquinolin-1-yl)ethan-1-one is a cysteine-reactive small-molecule fragment for chemoproteomic and ligandability studies for both traditionally druggable proteins as well as 'undruggable,' or difficult-to-target, proteins. This fragment electrophile, or 'scout' fragment, can be used alone in fragment-based covalent ligand discovery or incorporated into bifunctional tools such as electrophilic PROTAC® molecules for targeted protein degradation as demonstrated by the Cravatt Lab Lab for E3 ligase discovery.
Legal Information
PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license
Other Notes
Technology Spotlight: Proteomic Ligandability AssessmentThe Proteome-Wide Potential for Reversible Covalency at CysteineElectrophilic PROTACs that degrade nuclear proteins by engaging DCAF16Proteome-wide covalent ligand discovery in native biological systems
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