VEGF Inhibitor; Flt2-11

Not available outside of the UK & Ireland.

Biochem/physiol Actions

Cell permeable: no

Reversible: no

Primary TargetVEGF

Product does not compete with ATP.

General description

An 11-amino acid peptide derived from the second Ig-like domain of vascular endothelial growth factor receptor-1 (VEGFR-1 or Flt-1) that is shown to inhibit angiogenesis in chick chorioallantoic membrane and inhibits VEGF-induced vascular permeability. Neither binds to vascular endothelial growth factor (VEGF) nor inhibits its binding to VEGFR. Reported to form a stable β-sheet structure and exists as a dimer in solution.

An 11-amino acid peptide derived from the second Ig-like domain of vascular endothelial growth factor receptor-1 (VEGFR-1 or Flt-1) that is reported to inhibit angiogenesis in chick chorioallantoic membrane and VEGF-induced vascular permeability. Does not bind to vascular endothelial growth factor (VEGF) nor inhibit its binding to VEGFR. Reported to form a stable β-sheet structure and exists as a dimer in solution.

Legal Information

Sold under license of U.S. Patent 6,200,954.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Tan, D.C., et al. 2001. FEBS Lett.494, 150.

Packaging

1 mg in Plastic ampoule

Packaged under inert gas

Sequence

H-Asn-Ile-Thr-Val-Thr-Leu-Lys-Lys-Phe-Pro-Leu-OH

Warning

Toxicity: Standard Handling (A)