Non disponible en dehors du Royaume-Uni et de l'Irlande
Biochem/physiol Actions
Reversible: yes
Target IC50: 10 µM against protein kinase C
Product does not compete with ATP.
Primary TargetPKC
Cell permeable: yes
General description
A potent synthetic anti-estrogen. A cell-permeable and reversible inhibitor of protein kinase C (IC50 = 10 µM). Induces apoptosis in human malignant glioma cell lines.
A potent synthetic anti-estrogenic agent. A cell-permeable and reversible inhibitor of protein kinase C (IC50 = 10 µM). Induces apoptosis in human malignant glioma cell lines and inhibits prostate cancer cell growth by induction of p21 protein.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Other Notes
Rohlff, C., et al. 1998. Prostate 37, 51.Couldwell, W.J., et al. 1994. FEBS Lett.345, 43.Baltuch, G.H., et al. 1993. Neurosurgery33, 495.Powis, G. 1991. Trends Pharmacol. Sci.12, 188.Issandou, M., et al. 1990. Cancer Res.50, 5845.O'Brian, C.A., et al. 1985. Cancer Res.45, 2462.
Packaging
100 mg in Glass bottle
Reconstitution
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Warning
Toxicity: Harmful & Carcinogenic / Teratogenic (E)
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