Non disponible en dehors du Royaume-Uni et de l'Irlande
Biochem/physiol Actions
Reversible: yes
Product does not compete with ATP.
Target Ki: 460 nM against the pituitary multicatalytic proteinase complex (MPC)
Primary TargetMPC
Cell permeable: yes
General description
A potent, cell-permeable, and reversible proteasome inhibitor. Inhibits the chymotrypsin-like activity of the pituitary multicatalytic proteinase complex (MPC; Ki = 460 nM). Does not inhibit the peptidyl-glutamyl peptide hydrolyzing activity of MPC even at concentrations of 200 µM. Also blocks the decay of IκB-α and IκB-β proteins in exponentially growing WEHI 231 cells.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Other Notes
Schauer, S.L., et al. 1998. J. Immunol. 160, 4398.Orlowski, M., et al. 1997. Biochemistry 36, 13946.Orlowski, M., et al. 1993. Biochemistry 32, 1563.
Packaging
1, 5 mg in Plastic ampoule
Reconstitution
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months.
Sequence
Z-Leu-Leu-Phe-CHO
Warning
Toxicity: Standard Handling (A)
Ce produit répond aux critères suivants pour être admissible aux récompenses suivantes :