Non disponible en dehors du Royaume-Uni et de l'Irlande
Biochem/physiol Actions
Cell permeable: no
Reversible: no
Product does not compete with ATP.
Primary Targetserine proteases
General description
Irreversible inhibitor of serine proteases. Its mechanism of action is analogous to that of diisopropylfluorophosphate. PMSF causes sulfonylation of the active-site serine residues. Also reported to inhibit internucleosomal DNA fragmentation in immature thymocytes. Effective at a concentration of 50 µM.
Irreversible inhibitor of serine proteases. Its mechanism of action is analogous to that of diisopropylfluorophosphate. PMSF causes sulfonylation of the active-site serine residues. Also reported to inhibit internucleosomal DNA fragmentation in immature thymocytes. For a related, more stable inhibitor, see AEBSF (Cat. No. 101500).
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Other Notes
Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Seitz, R., et al. 1993. Int. J. Cancer53, 514.Weaver, V.M., et al. 1993. Biochem. Cell. Biol.71, 488.Bourgain, R.H., et al. 1992. Adv. Exp. Med. Biol.316, 427.Chang, C.T., et al. 1992. Biochem. Int.28, 707.
Packaging
5 g in Glass bottle
1 g in Alu drum
25 g in Fibre case
Reconstitution
t½ = 1 hour at pH 7.5. Effective concentration: 50 µM.
Following reconstitution, refrigerate (4°C). Stock solutions are stable for up to 9 months at 4°C.
Warning
Toxicity: Corrosive (L)
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