Pétérostilbene; Pterocarpus marsupium

Non disponible en dehors du Royaume-Uni et de l'Irlande

Biochem/physiol Actions

Reversible: no

Product does not compete with ATP.

Primary TargetCOX-1 and COX-2 activities

Cell permeable: yes

Target IC₅₀: 19.8 µM, 83.9 µM against COX-1 and -2 activities, respectively; 70 µM for inducing apoptosis in HL60 cells; ED50 = 4.8 µM for preventing DMBA-induced preneoplastic lesions

General description

A cell-permeable methoxylated analog of Resveratrol (Cat. No. 554325) that displays antioxidant, antiproliferative, and hypoglycemic properties. Moderately inhibits COX-1 and -2 activities (IC₅₀ = 19.8 µM and 83.9 µM) respectively, induces apoptosis in HL60 cells (IC₅₀ = 70 µM), prevents DMBA-induced preneoplastic lesions (ED₅₀ = 4.8 µM) and decreases plasma glucose level in streptozotocin-induced diabetic rats comparable to that of Metformin.

A cell-permeable methoxylated analog of Resveratrol (Cat. No. 554325) that displays antioxidant, anti-proliferative, and hypoglycemic properties. Appears to be a better free radical scavenger than Trolox (Cat. No. 64847). Moderately inhibits COX-1 & COX-2 activities (IC₅₀ = 19.8 µM & 83.9 µM, respectively) and induces apoptosis in HL60 cells (IC₅₀ = 70 µM). Also prevents DMBA-induced pre-neoplastic lesions (ED₅₀ = 4.8 µM). Reported to decrease plasma glucose levels in streptozotocin-induced diabetic rats comparable to that of Metformin.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Roberti, M., et al. 2003. J. Med. Chem.46, 3546.Rimando, A.M., et al. 2002. J. Agric. Food Chem.50, 3453.Manickam, M., et al. 1997. J. Nat. Prod.60, 609.

Packaging

Packaged under inert gas

10 mg in Glass bottle

Reconstitution

Following reconstitution, aliquot and freeze (-20°C.). Stock solutions are stable for up to 6 months at -20°C.

Warning

Toxicity: Carcinogenic / Teratogenic (D)