Non disponible en dehors du Royaume-Uni et de l'Irlande
Biochem/physiol Actions
Primary TargetNa+ and Ca2+ channels
General description
A benzisoxazole derivative that acts as an antiepileptic agent and is shown to block voltage-dependent Na(+) channels and T-type Ca(2+) channels. However, it does not serve as anticonvulsant agent in chemically induced seizures in flurothyl and pentetrazole models. Acts as an inhibitor of monoamine oxidase B (MAO-B; IC50 = 24.8 µM). Displays neurprotective properties.
A benzisoxazole derivative that acts as an antiepileptic agent and is shown to block voltage-dependent Na(+) channels and T-type Ca(2+) channels. However, it does not serve as anticonvulsant agent in chemically induced seizures in flurothyl and pentetrazole models. Acts as an inhibitor of monoamine oxidase B (MAO-B; IC50 = 24.8 µM). Displays neurprotective properties.Please note that the molecular weight for this compound is batch-specific due to variable water content.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Other Notes
Sonsalla, P.K., et al. 2010. Exp. Neurol.221, 329.Sobieszek, G. et al. 2003. Pol. J. Pharmacol.55, 68.
Packaging
10 mg in Glass bottle
Warning
Toxicity: Harmful (C)
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