Ouabain; Octahydrate

Non disponible en dehors du Royaume-Uni et de l'Irlande

Biochem/physiol Actions

Cell permeable: no

Reversible: no

Primary TargetNa⁺,K⁺-ATPase

Product does not compete with ATP.

General description

Inhibits Na⁺,K⁺-ATPase. Exhibits cardiotonic properties. Preferentially enhances radiotoxicity in tumor cells and induces apoptosis by prolonging the irradiation-induced G₂ delay.

Inhibits Na⁺ and K⁺-dependent ATPases. Has cardiotonic properties.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

Verheye-Dua, F.A., and Bohm, L. 2000. Strahlenther Onkol. 176, 186.Hasenauer, J., et al. 1993. J. Biol. Chem.268, 3289.Rakowski, F.F. 1993. J. Gen. Physiol.101, 117.Mahaney, J.E., and Grisham, C.M. 1992. Biochemistry31, 2025.Xu, Z.J., et al. 1992. J. Physiol.456, 405.

Packaging

1 g in Glass bottle

Reconstitution

Following reconstitution, aliquot and freeze (-20°C) for long-term storage or refrigerate (4°C) for short-term storage. Stock solutions are stable for up to 2 weeks at 4°C or for up to 2 months at -20°C.

Warning

Toxicity: Toxic (F)