Non disponible en dehors du Royaume-Uni et de l'Irlande
Biochem/physiol Actions
Reversible: yes
Product competes with ATP.
Target Ki: 2 nM, 4 nM and 52 nM for JNK1, 2 and 3, respectively
Cell permeable: yes
General description
A cell-permeable pyridinylamide compound that acts as an ATP-competitive, reversible inhibitor of JNK (Ki = 2 nM, 4 nM and 52 nM for JNK1, 2 and 3, respectively) and displays excellent selectivity over 72 other kinases. Inhibits c-jun phosphorylation with an EC50 of 920 nM in HepG2 cells. Preferentially blocks the growth of PTEN null mouse embryonic fibroblasts.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Other Notes
Vivanco, I., et al. 2007. Cancer Cell11, 555.Szczepankiewicz, B. G., et al. 2006. J. Med. Chem.49, 3563.
Packaging
Packaged under inert gas
5 mg in Plastic ampoule
Warning
Toxicity: Standard Handling (A)
Ce produit répond aux critères suivants pour être admissible aux récompenses suivantes :