Non disponible en dehors du Royaume-Uni et de l'Irlande
Biochem/physiol Actions
Reversible: no
Product competes with ATP.
Target IC50: 5 nM against GSK-3α/β
Cell permeable: yes
General description
A cell-permeable, highly potent, selective, reversible, and ATP-competitive inhibitor of GSK-3α/β (IC50 = 5 nM). Specificity was confirmed using various Cdk′s (IC50 = 83 nM for Cdk5/p25, 300 nM for Cdk2/cyclin A, 320 nM for Cdk1/cyclin B, and 10 µM for Cdk4/cyclin D1), MAP kinases, PKA, PKC isoforms, PKG, CK, and IRTK (IC50 ≥ 10 µM). Inhibition of GSK by BIO has been shown to result in the activation of the Wnt signaling pathway and sustained pluripotency of human and murine embryonic stem cells (ESCs).
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Other Notes
Polychronopoulos, P., et al. 2004. J. Med. Chem.47, 935.Sato, N., et al. 2004. Nat. Med.10, 55.Meijer, L., et al. 2003. Chem. Biol.10, 1255.
Packaging
Packaged under inert gas
500 µg in Plastic ampoule
Physical form
A 10 mM (500 µg/140 µl) solution of GSK-3 Inhibitor IX (Cat. No. 361550) in DMSO.
Warning
Toxicity: Carcinogenic / Teratogenic (D)
Ce produit répond aux critères suivants pour être admissible aux récompenses suivantes :