Non disponible en dehors du Royaume-Uni et de l'Irlande
Biochem/physiol Actions
Reversible: no
Product does not compete with ATP.
Primary TargetBCRP/ABCG2 (breast cancer resistance protein/ATP-binding cassette G2)
Cell permeable: yes
General description
A cell-permeable indolyldiketopiperazinyl mycotoxin that inhibits the ATPase and multidrug resistance activity of BCRP/ABCG2 (breast cancer resistance protein/ATP-binding cassette G2) without affecting the activity of MDR1. Also acts as a potent and specific chemosenzitizing agent. Suggested concentration for cell inhibition studies: ~1-5 µM.
A cell-permeable indolyldiketopiperazinyl mycotoxin that inhibits BCRP/ABCG2 (breast cancer resistance protein/ATP-binding cassette G2) multidrug transport activity. Also acts as a potent and specific chemosenzitizing agent.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Other Notes
Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Allen, J.D., et al. 2002. Mol. Cancer Ther.1, 417.Ozvegy, C., et al. 2001. Biochem. Biophys. Res. Commun.285, 111.Rabindran, S.K., et al. 2000. Cancer Res.60, 47.Rabindran, S.K., et al. 1998. Cancer Res.58, 5850.Cole, R.J., et al. 1977. J. Agric. Food Chem.25, 826.
Packaging
Packaged under inert gas
250 µg in Plastic ampoule
Reconstitution
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Warning
Toxicity: Toxic (F)
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