Non disponible en dehors du Royaume-Uni et de l'Irlande
Biochem/physiol Actions
Reversible: no
Target IC50: 42 nM against Flt-3
Product competes with ATP.
Cell permeable: yes
General description
A cell-permeable thienylcarboxamide compound that acts as a potent, ATP-competitive, and highly selective Flt-3 inhibitor (IC50 = 42 nM) with little effect against a panel of 22 other kinases (IC50 ≥3 µM). Shown to exhibit antiproliferative properties against the human acute myelogenous leukemia cell line MV4-11 (IC50 = 340 nM) expressing constitutively active Flt-3.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Other Notes
Patch, R.J., et al. 2006. Bioorg. Med. Chem. Lett.16, 3282.
Packaging
Packaged under inert gas
5 mg in Plastic ampoule
Warning
Toxicity: Irritant (B)
Ce produit répond aux critères suivants pour être admissible aux récompenses suivantes :