Non disponible en dehors du Royaume-Uni et de l'Irlande
Biochem/physiol Actions
Reversible: no
Target IC50: 2.24 nM against cathepsin B
Primary Targetcathepsin B
Product does not compete with ATP.
Cell permeable: yes
General description
A cell-permeable analog of CA-074 (Cat. No. 205530) that acts as an irreversible inhibitor of intracellular cathepsin B.
A cell-permeable analog of CA-074 (Cat. No. 205530) that acts as an irreversible inhibitor of intracellular cathepsin B. Reported to inhibit bone resorption in rodent models and shown to inhibit B16 melanoma cell invasion in vitro.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Other Notes
Sever, N., et al. 2002. Biol. Chem.383, 839.Authier, F., et al. 1999. J. Biol. Chem.274, 33723.Hill, P.A., et al. 1994. J. Cell Biochem. 56, 118.Buttle, D.J., et al. 1992. Arch. Biochem. Biophys. 299, 377.
Packaging
1 mg in Plastic ampoule
Reconstitution
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Warning
Toxicity: Standard Handling (A)
Ce produit répond aux critères suivants pour être admissible aux récompenses suivantes :