Non disponible en dehors du Royaume-Uni et de l'Irlande
Biochem/physiol Actions
Reversible: no
Product does not compete with ATP.
Primary TargetNADPH oxidase
Cell permeable: yes
General description
A cell-permeable, anti-inflammatory phenol that acts as a potent and selective inhibitor of NADPH oxidase. Also blocks peroxynitrite formation in murine macrophages. Reported to increase glutathione synthesis through the activation of AP-1. Shown to prevent phagocytosis of myelin by macrophages (10 mM).
A cell-permeable, anti-inflammatory phenolic compound that acts as a potent and selective inhibitor of NADPH oxidase. Shown to block peroxynitrite formation in murine macrophages. Reported to increase glutathione synthesis through activation of AP-1. Also reported to prevent phagocytosis of myelin by macrophages (10 mM).
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Other Notes
Abid, M.R., et al. 2000. FEBS Lett.486, 252.Muijsers, R.B., et al. 2000. Br. J. Pharmacol.130, 932.Lapperre, T.S., et al. 1999. FEBS Lett.443, 235.Supinski, G., et al. 1999, J. Appl. Physiol.87, 776.van der Goes, A., et al. 1998. J. Neuroimmunol.92, 67.Hart, B.A., and Simmons, J.M. 1992. Biotechnol. Ther.3, 3.
Packaging
Packaged under inert gas
1 g in Plastic ampoule
Reconstitution
Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Warning
Toxicity: Irritant (B)
Ce produit répond aux critères suivants pour être admissible aux récompenses suivantes :