Non disponible en dehors du Royaume-Uni et de l'Irlande
General description
Recombinant, human ACE-2 ectodomain (amino acids 1-740) fused at the C-terminus to a His Tag™ sequence and expressed in NSO cells. ACE-2 cleaves angiotensins I and II as a carboxypeptidase and plays an important role in regulating cardiovascular and renal functions. Native ACE-2 is an integral membrane zinc metalloprotease whose activity is inhibited by EDTA. By SDS-PAGE, the apparent molecular mass of the glycosylated protein is ~120 kDa under either reducing or non-reducing conditions.
Recombinant, human ACE-2 ectodomain (amino acids 1-740) fused at the C-terminus to a His Tag™ sequence and expressed in NSO cells. Native ACE-2 is an integral membrane zinc metalloprotease that can be inhibited by EDTA. ACE-2 cleaves angiotensins I and II. Plays an important role in regulating cardiovascular and renal functions. By SDS-PAGE, the apparent molecular mass of the glycosylated protein is ~120 kDa under either reducing or non-reducing condition.
Legal Information
HIS TAG is a registered trademark of Merck KGaA, Darmstadt, Germany
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Other Notes
Tikellis, C., et al. 2003. Hypertension41, 390.Tipnis, S.R., et al. 2000. J. Biol. Chem.275, 33238.
Packaging
10 µg in Glass bottle
Please refer to vial label for lot-specific concentration.
Reconstitution
Following initial thaw, aliquot and freeze (-70°C).
Unit Definition
One unit is defined as the amount of enzyme that will cleave 1 nmol MCA-YVADAPK(DNP)-OH per min at 25°C, pH 7.5.
Warning
Toxicity: Standard Handling (A)
Ce produit répond aux critères suivants pour être admissible aux récompenses suivantes :