Non disponible en dehors du Royaume-Uni et de l'Irlande
Biochem/physiol Actions
Reversible: no
Product does not compete with ATP.
Cell permeable: yes
Primary TargetPARP
General description
A cell-permeable anti-proliferative agent that acts as an inhibitor of poly(ADP-ribose) polymerase (PARP). Has minimal effect on bacterial toxin-mediated ADP-ribosylation. An inhibitor of UV-induced apoptosis. Also strongly inhibits K562 target cell killing by human effector natural killer cells.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Other Notes
Tiozzo, R., et al. 1996. Biochem. Biophys. Res. Commun. 225, 826.Malorni, W., et al. 1995. Biochem. Biophys. Res. Commun. 207, 715.Malorni, W., et al. 1994. Biochem. Biophys. Res. Commun. 199, 1250.Monti, D., et al. 1994. Biochem. Biophys. Res. Commun.199, 525.Kozak, K.R., and Ross, I.A. 1991. Biochem. Biophys. Res. Commun.179, 1225.
Packaging
100 mg in Plastic ampoule
Reconstitution
Following reconstitution, aliquot and freeze (-20°C ). Stock solutions are stable for 3 months at -20°C.
Warning
Toxicity: Irritant (B)
Ce produit répond aux critères suivants pour être admissible aux récompenses suivantes :