Amilure; hydrochlorure

Non disponible en dehors du Royaume-Uni et de l'Irlande

Biochem/physiol Actions

Target IC₅₀: 130 µM inhibiting capillary morphogenesis completely and reversibly

Cell permeable: no

Reversible: yes

Product does not compete with ATP.

Primary Targetcapillary morphogenesis

General description

An inhibitor of angiogenesis. At low concentrations, acts as a potent and specific inhibitor of transmembrane Na+ entry and Na⁺/H⁺ ATPase. Inhibits smooth muscle responses to contractile stimuli. Blocks palytoxin-induced conductance in skeletal muscle. Reduces the electrical potential across tubular epithelium. At higher concentrations, blocks the Na⁺/H⁺ exchange pathway.

An inhibitor of angiogenesis. Inhibits capillary morphogenesis completely and reversibly at approximately 130 µM. At low concentrations, acts as a potent and specific inhibitor of transmembrane Na⁺ entry and Na⁺,K⁺-ATPase. Also acts as an inhibitor of urokinase-type plasminogen activator (uPA). Blocks smooth muscle responses to contractile stimuli and palytoxin-induced conductance in skeletal muscle. Reduces electrical potential across tubular epithelium. At higher concentrations, blocks the Na⁺/H⁺ exchange pathway.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

Knoll, A., et al. 1999. Microvasc. Res.58, 1.Swiercz, R., et al. 1999. Oncol. Rep.6, 523.Moran, A., et al. 1995. Am. J. Physiol. 268, C350.Alliegro, M.C., et al. 1993. J. Exp. Zool. 267, 245.Sugiyama, S., et al. 1988. J. Biol. Chem.263, 8215.Yoshida, K., et al. 1988. Biochem. Biophys. Res. Commun.154, 101.Sariban-Sotorabay, S., and Benos, D.J. 1986. Am. J. Physiol.250, C175.

Packaging

100 mg in Alu drum

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Aqueous stock solutions are stable for up to 6 months at -20°C.

Warning

Toxicity: Toxic (F)