TH1020

Non disponible en dehors du Royaume-Uni et de l'Irlande

Application

TH1020 has been used to inhibit toll-like receptor 5 (TLR5) in porcine intestinal epithelial monolayer cells and mice.

Biochem/physiol Actions

TH1020 mediates the inhibition of tumor necrosis factor-α (TNF-α) based signaling, It disrupts tetrameric complex by binding the molecular interface between dimeric TLR5.

TH1020 is a non-cytotoxic non-cytotoxic toll-like receptor 5 (TLR5)/flagellin complex inhibitor. TH1020 selectively prevents flagellin-induced TLR5 signaling without affecting ligands-induced activation of TLR2, TLR3, TLR4, TLR7 or TLR8.

Packaging

5, 25 mg in glass bottle