C14 cersoc (D18 :1 / 14 : 0)

Non disponible en dehors du Royaume-Uni et de l'Irlande

Application

C14 Ceramide (d18:1/14:0) is suitable for useas a standard in high-performance liquid chromatography/tandem mass spectrometry (LC/MS²) for ceramide quantification from muscel biopsiesin lipid monolayer preparation for biophysical studiesin the morphological and dimensional evaluation studies

Biochem/physiol Actions

Ceramides regulate biological processes including proliferation, differentiation and apoptosis. In the cystic fibrosis patients, elevated levels of C14 ceramide is observed. It is also a potential biomarker for hepatic steatosis (HS) and C14 ceramide levels correlate with the aspartate aminotransferase (AST) / alanine transaminase (ALT) ratio. Tumor necrosis factor α (TNFα) mediates increase in the C14 levels. Fumonisin B1 prevents the C14 accumulation.

General description

Ceramide synthesis is majorly driven by de novo pathway involving the palmitoyl-CoA and L-serine, and also by salvage pathway via recycling of complex sphingolipids. The ceramide transporter, Cert mediates the transfer of C14 from smooth endoplasmic reticulum to Golgi. Ceramide synthase CerS6 enzyme is involved in the synthesis of C14 ceramide.

Packaging

5 mL Amber Glass Screw Cap Vial (860514P-5mg)

5 mL Amber Glass Screw Cap Vial (860514P-25mg)