#-SECRETASE inhibiteur I 1 pc x 1 MG

Non disponible en dehors du Royaume-Uni et de l'Irlande

Biochem/physiol Actions

Reversible: no

Product does not compete with ATP.

Primary Targetγ-secretase

Cell permeable: yes

General description

Inhibits γ-secretase, a protease that cleaves the amyloid precursor protein (APP). Inhibition of this enzyme is believed to aid in the prevention of Alzheimer′s disease.

Cell permeable. Inhibits γ-secretase, a protease that cleaves the Amyloid Precursor Protein (APP) to generate β-amyloid protein. Inhibition of this enzyme is believed to aid in the prevention of Alzheimer's disease.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Skovronsky, D.M., et al. 2000. Biochemistry 39, 810.Hartmann, T., et al. 1997. Nat. Med. 3, 1016.

Packaging

1 mg in Plastic ampoule

Packaged under inert gas

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Sequence

Z-Leu-Leu-Nle-CHO (Nle = Norleucine)

Warning

Toxicity: Standard Handling (A)