(+/-)-Baclofen, >=98% (TLC), solid

Not available outside of the UK & Ireland.

Application

(±)-Baclofen has been used as γ-aminobutyric acid receptor B GABA_Breceptor agonist: as well as control GABAergic drug to test its protective effects on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced dopaminergic toxicityto test its effects on in vivo motor function tests and performance of mutant miceto test its excitability effect on dopaminergic (DA) neurons of the ventral tegmental area (VTA) to test its effect in reducing dendritic excitability in Purkinje neurons

Biochem/physiol Actions

GABA_B receptor agonist; skeletal muscle relaxant; antispastic agent.

Baclofen, a γ-aminobutyric acid (GABA) analog, possesses myorelaxant properties Being a γ-aminobutyric acid receptor B (GABA_B) agonist, baclofen may be involved in the potentiation of dendritic potassium K⁺channels. It may be useful in blocking transient lower esophageal sphincter relaxation (TLESR)in gastroesophageal reflux disease (GERD). Baclofen may also have scope for treating addictive especially, in alcohol use disorder (AUD).