Creatine Kinase MB Fraction from human heart, >=70% (SDS-PAGE), liquid

Not available outside of the UK & Ireland.

Application

Enzyme associated with coronary performance.

The MB isoenzyme of creatine kinase (MBCK) can be used as a diagnostic marker for acute myocardial infarction.

Biochem/physiol Actions

Creatine Kinase (CK) catalyzes the formation of creatinine from creatine phosphate. Elevated serum levels of CK-MB are prime indicators of myocardial cellular injury. It is regarded as a “gold standard” for myocardial infarction diagnosis. The levels of cardiac troponin I (cTnI) or cardiac troponin T also correlate to higher CK-MB) levels. CK-MB levels may also be elevated in chronic renal failure.

Components

Solution in 5 mM sodium succinate, 10 mM sodium chloride, 1 mM EDTA, 5 mM β-mercaptoethanol, 50% glycerol, pH 7.0.

General description

Creatine Kinase (CK) comprises M and B subunit and is a dimeric molecule. It is one among the isoenzymes of CK. The enzyme is majorly present in the myocardium.