Hydrate de cholate de Sodium, adapté à la culture cellulaire, bioréactif

Code: c9282-100g D2-231

Non disponible en dehors du Royaume-Uni et de l'Irlande

Application

Cholate is a bile acid produced in liver during cholesterol breakdown. Cholate downregulates cholesterol-7-A-hydroxylase (rate-limiting step in bile acid synthesi...


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Votre prix
$425.40 100G
DEMANDER

Non disponible en dehors du Royaume-Uni et de l'Irlande

Application

Cholate is a bile acid produced in liver during cholesterol breakdown. Cholate downregulates cholesterol-7-A-hydroxylase (rate-limiting step in bile acid synthesis). Cholate, an anionic detergent, is used alone and in combination with urea to extract and reconstitute membrane proteins and protein complexes.

Sodium cholate hydrate has been used:as a bile acid to induce bile acid-responsive (BEAR) transcription system, as a component of Campylobacter defined broth (CDB) to test its effect on stress response in Campylobacter jejuni{52to test its sensitivity towards the bile acid sensor

Biochem/physiol Actions

Reduction in 12-α hydroxylase activity leads to low levels of cholic acid in liver disease.

General description

Cholate is a primary bile acid produced from cholesterol in the liver. It is an anionic detergent synthesized from cholesterol in the presence of sterol 12α-hydroxylase (CYP8B1).

Packaging

25, 100 g in poly bottle

aggregation number2-3
assay≥99.0% (HPLC)
biological sourcebovine bile, ovine bile
CMC9-15 mM (20-25°C)
descriptionanionic
formpowder
HLB18
InChI keyMUVVIYFKOVLQHL-RCVKHMDESA-M
InChI1S/C24H40O5.Na.H2O/c1-13(4-7-21(28)29)16-5-6-17-22-18(12-20(27)24(16,17)3)23(2)9-8-15(25)10-14(23)11-19(22)26;;/h13-20,22,25-27H,4-12H2,1-3H3,(H,28,29);;1H2/q;+1;/p-1/t13-,14+,15-,16-,17+,18+,19-,20+,22+,23+,24-;;/m1../s1
mol wtmicellar avg mol wt 900-1300
product lineBioReagent
Quality Level200
SMILES stringO.[Na+].C[C@H](CCC([O-])=O)C1CCC2C3[C@H](O)CC4C[C@H](O)CC[C@]4(C)C3C[C@H](O)[C@]12C
solubilitywater: 100 mg/mL, clear, colorless to light yellow
technique(s)cell culture | mammalian: suitable
Cas Number206986-87-0
Pack100G
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