Deshydroxy LY - 411575 ,>=98% (HPLC)

Non disponible en dehors du Royaume-Uni et de l'Irlande

Application

Deshydroxy LY-411575 has been used in dibenzazepine (DBZ) treatment and chemical treatment.

Biochem/physiol Actions

LY411575 prevents SPP (signal peptide peptidase) dependent cleavage of HCV (hepatitis C virus) core protein.

Deshydroxy LY-411575 is a cell-permeable γ-secretase inhibitor and inhibtor of Notch processing. Deshydroxy LY-411575 significantly lowers both brain and plasma Aβ40 levels by ~72% in Tg2576 mutant APP transgenic mouse model and potently blocks Notch processing, with an IC₅₀ of 1.7 nM in SupT1 cells.

Packaging

5, 25 mg in glass bottle