Retrorsine, >=90% (HPLC)

Code: r0382-500mg D2-231

Not available outside of the UK & Ireland.

Application

Retrorsine has been used:as a mito-inhibitory pyrrolizidine alkaloid compound to induce necrotic liver injury in rats to induce hepatocellular injury in rats to a...


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$1,044.65 500MG
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Not available outside of the UK & Ireland.

Application

Retrorsine has been used:as a mito-inhibitory pyrrolizidine alkaloid compound to induce necrotic liver injury in rats to induce hepatocellular injury in rats to arrest endogenous hepatocyte growth in mice

Biochem/physiol Actions

Retrorsine (RTS) is a retronecine-type pyrrolizidine alkaloid associated with SenecioandCrotalariaspecies. It belongs to the pyrrolizidine alkaloid family with mito-inhibitory property and elicits hepatotoxicity. It mediates the inactivation of cytochrome P450 3A4. Retrorsine also inhibits replication of fully differentiated hepatocytes.

assay≥90% (HPLC)
InChI keyBCJMNZRQJAVDLD-CQRYIUNCSA-N
InChI1S/C18H25NO6/c1-3-12-8-11(2)18(23,10-20)17(22)24-9-13-4-6-19-7-5-14(15(13)19)25-16(12)21/h3-4,11,14-15,20,23H,5-10H2,1-2H3/b12-3-/t11-,14-,15-,18-/m1/s1
mp208-211 °C (lit.)
Quality Level100
SMILES stringCC=C1C[C@@H](C)[C@](O)(CO)C(=O)OCC2=CCN3CC[C@@H](OC1=O)[C@@H]23
Cas Number480-54-6
Hazard Class6.1
Un Number1544
Pack Group2
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