Carmofur, >=98% (HPLC), powder

Code: c1494-10mg D2-231

Not available outside of the UK & Ireland.

Application

Carmofur has been used as an inhibitor of acid ceramidase to study its effects on glucosylsphingosine (GlcSph) production in human embryonic kidney 293T (HEK293T)...


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Your Price
$131.25 10MG
REQUEST

Not available outside of the UK & Ireland.

Application

Carmofur has been used as an inhibitor of acid ceramidase to study its effects on glucosylsphingosine (GlcSph) production in human embryonic kidney 293T (HEK293T) cells. It has also been used as an inhibitor of acid ceramidase to study its effects on acid‐mediated hydrolysis of ceramide which kicks-in consumption and the generation of sphingosine .

Biochem/physiol Actions

Carmofur is a derivative of fluorouracil, an antimetabolite used as an antineoplastic agent.

Carmofur acts as an inhibitor of fatty acid amide hydrolase (FAAH), N-acylethanolamine acid amidase (NAAA) and acid ceramidase (ASAH1). Carmofur has a therapeutic activity against colorectal and cervical cancer. It can inhibit the severe acute respiratory syndrome (SARS)-CoV-2 main protease (Mpro) in vitro.

Packaging

10, 50 mg in glass bottle

assay≥98% (HPLC)
colorwhite to off-white
formpowder
InChI keyAOCCBINRVIKJHY-UHFFFAOYSA-N
InChI1S/C11H16FN3O3/c1-2-3-4-5-6-13-10(17)15-7-8(12)9(16)14-11(15)18/h7H,2-6H2,1H3,(H,13,17)(H,14,16,18)
Quality Level100
SMILES stringCCCCCCNC(=O)N1C=C(F)C(=O)NC1=O
solubilityDMSO: >15 mg/mL
storage temp.2-8°C
Cas Number0061422-45-5
Hazard Class6.1
Un Number2811
Pack Group2
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