ML239, >=98% (HPLC)

Not available outside of the UK & Ireland.

Application

ML239 has been used as a proble in cellular lipid profiling.

Biochem/physiol Actions

ML239 decreases the saturated and monounsaturated lysophosphatidylethanolamines in lung cancer cells and is toxic to breast cancer cells. ML239 may elicit toxicity by modulating the nuclear factor−κB (NF-κB) associated pathways.

ML239 is an inhibitor of breast cancer stem cells found from a screen using stem cell-like human mammary epithelial cells (HMLE). ML239 inhibited cancer stem cells with an IC₅₀ of 1.16 µM with 24-fold selectivity against the control cell line.

Packaging

5, 25 mg in glass bottle