Diethylumbelliferyl phosphate, >=98% (HPLC), oil

Not available outside of the UK & Ireland.

Application

Diethylumbelliferyl phosphate has been used as a lipase inhibitor to treat wild-type myeloblasts for in vitro neutrophil differentiation assays.

Biochem/physiol Actions

Diethylumbelliferyl phosphate is a selective, potent cholesterol esterase inhibitor. It blocks steroidogenesis primarily by preventing cholesterol transport into the mitochondria of steroidogenic cells. Inhibitors of cholesterol esterase are anticipated to limit the absorption of dietary cholesterol. IC₅₀ = 11.6 µM.

Diethylumbelliferyl phosphate (DEUP), an organophosphate does not block protein kinase activity A in vitro.

Packaging

5, 25 mg in glass bottle