Bisantrene dihydrochloride, >=98% (HPLC)

Code: B4563-50MG D2-231

Not available outside of the UK & Ireland.

Application

Bisantrene (NSC 337766), and its derivatives are topoisomerase II poisons and DNA intercalators. It may be used as model compounds to study P-glycoprotein-mediate...


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$399.82 50MG
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Not available outside of the UK & Ireland.

Application

Bisantrene (NSC 337766), and its derivatives are topoisomerase II poisons and DNA intercalators. It may be used as model compounds to study P-glycoprotein-mediated multiple drug resistance (MDR1). Bisantrene may be used as a Rac1 inhibitor.

Biochem/physiol Actions

Bisantrene is an anthracene bishydrazone derivative, which has antitumor activity.

Bisantrene dihydrochloride is an antineoplastic agent, MDR1 substrate, DNA intercalator, and topoisomerase II poison. Cancer cells that develop resistance to bisantrene tend to overexpress P-glycoprotein. Bisantrene can be used to select for P-glycoprotein-mediated multiple drug resistance. The data suggest that bisantrene is an excellent substrate for P-glycoprotein.

Packaging

10, 50 mg in glass bottle

assay≥98% (HPLC)
formsolid
InChI keyKINULKKPVJYRON-PVNXHVEDSA-N
InChI1S/C22H22N8.2ClH/c1-2-6-16-15(5-1)19(13-27-29-21-23-9-10-24-21)17-7-3-4-8-18(17)20(16)14-28-30-22-25-11-12-26-22;;/h1-8,13-14H,9-12H2,(H2,23,24,29)(H2,25,26,30);2*1H/b27-13+,28-14+;;
Quality Level100
SMILES stringCl.Cl.C1CN=C(N1)NN=Cc2c3ccccc3c(C=NNC4=NCCN4)c5ccccc25
solubilitydeionized water: 8 mg/mL
storage temp.room temp
Cas Number0078186-34-2
Hazard Class6.1
Un Number2811
Pack Group3
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