17-(Allylamino)-17-demethoxygeldanamycin, >=98% (HPLC), solid

Not available outside of the UK & Ireland.

Application

17-(Allylamino)-17-demethoxygeldanamycin (17-AAG) has been used as a heat shock protein 90 (HSP90) inhibitor:to study its effects on hippocampal neuronsto analyze its effects on yes-associated protein (YAP) phosphorylation in adenocarcinoma human alveolar basal epithelialcells and human breast epithelialcellsto study its effects on lifespan extension and health in Caenorhabditis elegans

Biochem/physiol Actions

Potent inhibitor of heat shock protein 90 (Hsp90). 17-AAG is a less toxic analog than geldanamycin. It induces apoptosis and displays antitumor effects. 17-AAG inhibits the activity of oncogenic proteins such as N-ras, Ki-ras, c-Akt, and p185^erB2.

17-(Allylamino)-17-demethoxygeldanamycin (17-AAG) is a benzoquinone and is an analog of geldanamycin.

Features and Benefits

This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

General description

Chemical structure: benzenoid

Packaging

500 µg in glass bottle