Anticorps Monoclonal Anti - DNMT2 produit dans la souris, clone 1E12, immunoglobulin purifiée, solution aqueuse tamponnée

Non disponible en dehors du Royaume-Uni et de l'Irlande

Biochem/physiol Actions

DNA methyltransferase 2 (DNMT2) might be involved in de novo methylation of newly integrated retroviral DNA in mammalian DNA. DNMT2 functions as a tRNA methyltransferase in lower eukaryotes. DNMT2 plays an essential role in zebrafish development by enhancing cytoplasmic RNA methylation. DNMT2 promotes DNA methylation in Drosophila.

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General description

This gene encodes a protein responsible for the methylation of aspartic acid transfer RNA. While similar in sequence and structure to DNA cytosine methyltransferases, this gene is distinct and highly conserved in its function among taxa. Alternative splicing results in multiple transcript variants encoding different isoforms. (provided by RefSeq)

Immunogen

DNMT2 (AAH47733, 1 a.a. ~ 391 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.SequenceMEPLRVLELYSGVGGMHHALRESCIPAQVVAAIDVNTVANEVYKYNFHHTQLLAKTIEGITLEEFDRLSFDMILMSPPCQPFTRIGRQGDMTDSRTNSFLYILDILPRLQKLPKYILLENVKGFEVSSTRDLLIQTIENCGFQYQEFLLSPTSLGIPNSRLRYFLIAKLQSEPLPFQAPGQVLMEFPKIESVHPQKYAMDVEEKIQEKNVEPNISFDGSIQCSGKDAILFKLETAEEIHRKNQQDSDLSVKMLKDFLEDDTDVNQYLLPPKSLLRYALLLDIVQPTCRRSVCFTKGYGSYIEGTGSVLQTAEDVQVENIYKSLTNLSQEEQITKLLILKLRYFTPKEIANLLGFPPEFGFPEKITVKQRYRLLGNSLNVHVVAKLIKILYE

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Physical form

Solution in phosphate buffered saline, pH 7.4